David O'Connor


Position

Dean, Research & Graduate Studies

Head of Department


Qualifications

Ph.D.   University of Liverpool,  1983

M.Sc.   (with Distinction) in Biochemistry, University College London, UK,  1980

B.Sc.   (Hons) in Zoology & Biological Chemistry, University of Salford, UK,  1979


Experience

Dean, Research & Graduate Studies, XJTLU (2013 - Present), Suzhou, China-PRC.

Professor, Department of Biological Sciences at XJTLU (February, 2012 - Present), suzhou, China-PRC.  

Head, Department of Biological Sciences at XJTLU (February, 2012 - Present), Suzhou, China-PRC.

Acting Head, Department of Environmental Science at XJTLU (2012 - 2013), Suzhou, China-PRC.

Professor and Director, Centre for Proteomic Research, Centre for Biological Sciences, University of Southampton, UK (2001 - 2012), unknown, United Kingdom.

Reader, School of Biological Sciences, University of Southampton, UK (2000 - 2001), unknown, United Kingdom.

Senior Lecturer, School of Biological Sciences, University of Southampton, UK (1995 - 2000), unknown, United Kingdom.

Lecturer, Department of Biochemistry, University of Southampton, UK (1991 - 1995), unknown, United Kingdom.

Royal Society New Blood Lecturer, Department of Biochemistry, University of Southampton, UK (1986 - 1991), unknown, United Kingdom.

Royal Society Post-Doctoral Fellow, Department of Medical Biochemistry, University of Geneva Medical School, Switzerland (1984 - 1986), unknown, Switzerland.


Professional Service Activities 

Board Member: Board of Trustees

2011:  Governing Body, BBSRC Institute of Food Research (International).


Board Member: PRJ Editorial Review Board

2004:  - 2007: Proteomics, Editor and Reviewer (International).

1999:  - 2004: Journal of General Microbiology, Editor and Reviewer (International).


Invited Lecture

2013:  Keynote speaker, "Sixth World Protein & Peptide Conference - PepCon 2013, China (International).

2012:  Invited speaker, CAS Institute of Material Medica, Shanghai, China (International).

2010:  Chair and Invited Speaker, Joint BSPR-EBI symposium 'Proteomics: from the Qualitative to the Quantitative', Hinxton, UK (International).

2008:  Keynote speaker, First Irish Proteomics Workshop, Conway Institute, Ireland (International).

2007:  Chair and Invited speaker, Joint BSPR-EBI symposium on Integrated Proteomics, Hinxton, UK (International).

2005:  Chair and Invited speaker, UK-Texas collaborative workshop on infectious disease, Galveston, USA (International).

2004:  Invited speaker, Inaugural symposium of Conway Institute, Ireland (International).

2003:  Invited Main Symposium Speaker, Genomics Symposium, Society for General Microbiology, Manchester, UK (International).

2002:  Proteomics tour of West Coast of North America (Vancouver, Seattle, and University of California, Berkeley)(sponsored by the DTI), USA (International).

2002:  Keynote speaker, NATO Advanced Workshop on Toxicogenomics & Proteomics, Castle Stiren, Czech Republic (attendance sponsored by NATO) (International).

2002:  Invited speaker, First International Conference of the Human Proteome Organisation (HUPO) , Versailles, France (International).

2000:  Invited speaker, Wellcome Trust 'Functional Genomics Initiative' meeting, The Sanger Centre, (attendance sponsored by the Wellcome Trust) Hinxton, UK (International).

1999:  Invited speaker, Symposium on Proteomics, International Union of Microbiological Societies, IXth International Congress of Bacteriology & Applied Microbiology. Sydney, Australia (International).


Member: Committee/Task Force

2012 – 2013:  Member, Research Committee (Local).

2012 – 2013:  Member, Academic Committee (Local).

2012 – 2013:  Member, Promotion Review Panel (Local).

2012:  Internal Reviewer, Applied English Programme (Local).

2012:  Member, Panel for Internal Periodic Review of BEM (Local).

2012:  Contributor to development of Environmental Science Programme (Local).

2012:  Member, Research Information Systems Project Board (Local).

2011:  Chair, Science Committee, Governing Body, BBSRC Institute of Food Research (International).

2011:  Member, Funding Committee, European Proteomics Association (EuPA) (International).

2011:  Panel member, Romanian Research Assessment Exercise 2011 (organised by Executive Agency for Higher Education, Research, Development and Innovation Funding (UEFISCDI)) (International).

2011:  External Adviser, Wellcome Trust Strategic Awards Panel (International).

2011:  Member, GC11 Review Panel, Bill & Melinda Gates Foundation/Wellcome Trust (International).

2011:  Member, International Expert Panel, National Research Foundation, Singapore (International).


Reviewer: Ad Hoc Reviewer for a Journal

1999:  I have served as a reviewer for the following journals: (International).  Electrophoresis, EMBO J, Gut, Infection & Immunity, J Bacteriology, J Biological Chemistry, J Molecular Biology, Microbiology, Molecular & Cellular, Molecular Microbiology, Nature, PNAS.


Professional Service Activities 

Board Member: Board of Trustees

2011:  Governing Body, BBSRC Institute of Food Research (International).


Board Member: PRJ Editorial Review Board

2004:  - 2007: Proteomics, Editor and Reviewer (International).

1999:  - 2004: Journal of General Microbiology, Editor and Reviewer (International).


Invited Lecture

2013:  Keynote speaker, "Sixth World Protein & Peptide Conference - PepCon 2013, China (International).

2012:  Invited speaker, CAS Institute of Material Medica, Shanghai, China (International).

2010:  Chair and Invited Speaker, Joint BSPR-EBI symposium 'Proteomics: from the Qualitative to the Quantitative', Hinxton, UK (International).

2008:  Keynote speaker, First Irish Proteomics Workshop, Conway Institute, Ireland (International).

2007:  Chair and Invited speaker, Joint BSPR-EBI symposium on Integrated Proteomics, Hinxton, UK (International).

2005:  Chair and Invited speaker, UK-Texas collaborative workshop on infectious disease, Galveston, USA (International).

2004:  Invited speaker, Inaugural symposium of Conway Institute, Ireland (International).

2003:  Invited Main Symposium Speaker, Genomics Symposium, Society for General Microbiology, Manchester, UK (International).

2002:  Proteomics tour of West Coast of North America (Vancouver, Seattle, and University of California, Berkeley)(sponsored by the DTI), USA (International).

2002:  Keynote speaker, NATO Advanced Workshop on Toxicogenomics & Proteomics, Castle Stiren, Czech Republic (attendance sponsored by NATO) (International).

2002:  Invited speaker, First International Conference of the Human Proteome Organisation (HUPO) , Versailles, France (International).

2000:  Invited speaker, Wellcome Trust 'Functional Genomics Initiative' meeting, The Sanger Centre, (attendance sponsored by the Wellcome Trust) Hinxton, UK (International).

1999:  Invited speaker, Symposium on Proteomics, International Union of Microbiological Societies, IXth International Congress of Bacteriology & Applied Microbiology. Sydney, Australia (International).


Member: Committee/Task Force

2012 – 2013:  Member, Research Committee (Local).

2012 – 2013:  Member, Academic Committee (Local).

2012 – 2013:  Member, Promotion Review Panel (Local).

2012:  Internal Reviewer, Applied English Programme (Local).

2012:  Member, Panel for Internal Periodic Review of BEM (Local).

2012:  Contributor to development of Environmental Science Programme (Local).

2012:  Member, Research Information Systems Project Board (Local).

2011:  Chair, Science Committee, Governing Body, BBSRC Institute of Food Research (International).

2011:  Member, Funding Committee, European Proteomics Association (EuPA) (International).

2011:  Panel member, Romanian Research Assessment Exercise 2011 (organised by Executive Agency for Higher Education, Research, Development and Innovation Funding (UEFISCDI)) (International).

2011:  External Adviser, Wellcome Trust Strategic Awards Panel (International).

2011:  Member, GC11 Review Panel, Bill & Melinda Gates Foundation/Wellcome Trust (International).

2011:  Member, International Expert Panel, National Research Foundation, Singapore (International).


Reviewer: Ad Hoc Reviewer for a Journal

1999:  I have served as a reviewer for the following journals: (International).  Electrophoresis, EMBO J, Gut, Infection & Immunity, J Bacteriology, J Biological Chemistry, J Molecular Biology, Microbiology, Molecular & Cellular, Molecular Microbiology, Nature, PNAS.


Professional Memberships 

Fellow, Royal Society of Biology (FRSB), 2011 – Present

Member (and former President), British Society for Proteome Research, 1986 – Present

Member, American Society of Microbiology, 1986 - Present


Honors and Awards 

2016:  Visiting Professor, Suzhou Institute of Systems Medicine, Chinese Academy of Medicine.

2014:  Foreign Experts' Bureau Award, Ministry of Education, China.  Foreign Experts’ Bureau, Ministry of Education, China – ‘My Favourite Foreign Teacher in China’ Award (for setting up XJTLU Graduate School and related activities)   .

2012:  , Elected President, British Society for Proteome Research(2010-2012).

2012:  , SIP Jinji Lake Double-hundred Talents Programme Award.

2008:  , Appointed to Research Assessment Panel A5 (Other Laboratory-Based Clinical Subjects), RAE2008.




Research Interests 

Research Interests

Interests lie in the following areas:

1. Proteomics – applications and new approaches

Proteins are the ultimate effectors of essentially all cellular processes. They also form the basis for most vaccines and constitute over 95% of the known targets for therapeutic drugs (Drews. 2000. Science 287: 1960-1965). It follows that biological systems ultimately need to be explained in terms of the levels, interactions, regulation and modifications of proteins. Such an understanding presents enormous challenges as, in contrast to a genome, an organism’s proteome is dynamic and significantly more complex. By the same token, the large-scale identification, quantification and functional analysis of proteins – proteomics – promise a radical transformation of biological and medical research.

2. Molecular microbiology – host-pathogen interactions and survival/stress responses

In contrast to other organisms, microbes encounter a vast range of environments, many of which are potentially deleterious. They have therefore evolved efficient and diverse strategies to sense their surroundings and to ensure their continued survival. This is particularly the case for bacterial pathogens, which must cope with a multitude of host defence components in addition to specific stresses in the external environment. Knowledge at the molecular level of the ways in which bacteria detect and adapt to different stresses is not only of fundamental interest but will also allow the development of rational intervention strategies for reducing pathogen viability or virulence.
 

Publications 

Parkinson, E., Skipp, P., Aleksic, M., Garrow, A., Gadd, T., Hughes, M., Clough, G. and O'Connor, C.D. (2014).  Proteomic Analysis of the Human Skin Proteome after in vivo treatment with sodium dodecyl sulphate.   PLoS ONE, 9 (5), e97772, doi: 10.1371/journal.pone.0097772.


Parkinson, E., Boyd, P., Aleksic, M., Cubberley, R., & O'Connor, D. (2014).  Stable isotope labeling method for the investigation of protein haptenation by electrophilic skin sensitizers.   Toxicological Sciences, 142 (1), 239-249.


Jones, B.M., Iglesias-Rodriguez, M.D., Skipp, P.J., Edwards, R.J., Greaves, M.J., Young, J.R., Elderfield, H. & O'Connor, C.D. (2013).  Responses of the Emiliania huxleyi proteome to ocean acidification.   PLoS ONE, 8 (4), e61868, doi: 10.1371/journal.pone.0061868.


O'Connor, C.D. (2012).  Beyond the genome.   Public Service Review Europe, 24, 340-341.


Skipp, P.J & O'Connor, C.D. (2011).  Shotgun proteomics: future perspective in bioanalysis.   Bioanalysis, 3, 2159-2160.


Jones, B.M., Edwards, R.J., Skipp, P.J., O'Connor, C.D., & Iglesias-Rodriguez, M.D. (2011).  Shotgun proteomic analysis of Emiliania huxleyi, a marine phytoplankton species of major biogeochemical importance.   Marine Biotech., 13, 496-504.


Jones, J.D. & O'Connor, C.D. (2011).  Protein acetylation in prokaryotes.   Proteomics, 11, 3012-3022.


Gill, C., Parkinson, E., Church, M.K., Skipp, P., Scott, D., White, A.J., O'Connor, C.D. & Clough, G.F. (2011).  A qualitative and quantitative proteomic study of human microdialysate and the cutaneous response to injury.   AAPS J., 13, 309-317.


Mary, I., Oliver, A., Skipp, P., Holland, R., & Topping, J. (2010).  Metaproteomic and metagenomic analyses of defined oceanic microbial populations using microwave cell fixation and flow cytometric sorting.   FEMS Microbiol. Ecology, 74, 10-18.


Nicholas, B.L., Skipp, P., Barton, S., Singh, D., Bagmane, D., Mould, R., Angco, G., Ward, J., Guha-Niyogi, B., Wilson, S., Howarth, P., Davies, D.E., Rennard, S., O'Connor, C.D., & Djukanovi?, R. (2010).  Identification of lipocalin and apolipoprotein A1 as biomarkers of chronic obstructive pulmonary disease.   Am. J. Respir. Crit. Care Med., 181, 1049-1060.


Gulla, K., Gupta, K., Krarup, A., Gal, P., Schwaeble, W., Sim, R., O'Connor, C.D., & Hajela, K. (2010).  Activation of MBL-associated serine proteases (MASPs) leads to generation of a fibrin clot.   Immunology, 129, 482-495.


Williams, J.N., Skipp, P.J., O'Connor, C.D., Christodoulides, M., & Heckels, J.E. (2009).  Immunoproteomic analysis of the development of natural immunity in subjects colonized by Neisseria meningitidis reveals potential vaccine candidates.   Infect. Immun., 77, 5080-5089.


McDonald, R.A., Skipp, P., Bennell, J., Potts, C., Thomas, L., & O'Connor, C.D. (2009).  Mining whole-sample mass spectrometry proteomics data for biomarkers.   Expert Systems with Applications, 36, 5333-5340.


Thomson, N.R., Holden, M.T.G., Carder, C., Lennard, N., Lockey, S.J., Marsh, P., Skipp, P., O'Connor, C.D., Goodhead, I., Norbertzcak, H., Harris, B., Ormond, D., Rance, R., Quail, M.A., Parkhill, J., Stephens, R.S. & Clarke, I.N. (2008).  Chlamydia trachomatis: genome sequence analysis of Lymphogranuloma Venereum isolates.   Genome Res., 18, 161-171.


Williams, J.N., Skipp, P.J., Humphries, H.E., Christodoulides, M., O'Connor, C.D., & Heckels, J.E. (2007).  Proteomic Analysis of Outer Membranes and Vesicles from Wild-Type Serogroup B Neisseria meningitidis and a Lipopolysaccharide-Deficient Mutant.   Infect. Immun., 75, 1364-1372.


Nicholas, B., Skipp, P., Mould, R., Rennard, S., Davies, D., O'Connor, C.D. & Djukanovic, R. (2006).  Shotgun proteomic analysis of human-induced sputum.   Proteomics, 6, 4390-4401.


Vaughan, T.E., Skipp, P.J., O'Connor, C.D., Hudson, M.J., Vipond, R., Elmore, M.J. & Gorringe, A.R. (2006).  Proteomic analysis of Neisseria lactamica and Neisseria meningitidis outer membrane vesicle vaccine antigens.   Vaccine, 24, 5277-5293.


Skipp, P., Robinson, J., O'Connor, C.D., & Clarke, I.N. (2005).  Shotgun proteomic analysis of Chlamydia trachomatis.   Proteomics, 5, 1558-1573.


Owens, R.M., Pritchard, J.G., Skipp, P., Hodey, M., Connell, S.R., Nierhaus, K.H. & O'Connor, C.D. (2004).  A dedicated translation factor controls the synthesis of the global regulator Fis.   EMBO J., 23, 3375-3385.


Best, A., La Ragione, R.M., Cooley, W.A., O'Connor, C.D., Velge, P., & Woodward, M.J. (2003).  Interaction with avian (Div-1) cells and colonisation of specific pathogen free (SPF) chicks by shiga-toxin negative Escherichia coli O157:H7 (NCTC 12900).   Vet. Microbiol., 93, 207-222.


O'Connor, C.D. (2003).  DNA cloning: rise of the robots.   Heredity, 90, 415.


Grant, A.J., Farris, M., Alefounder, P., Williams, P.H., Woodward, M.J., & O'Connor, C.D. (2003).  Coordination of pathogenicity island expression by the BipA GTPase in enteropathogenic Escherichia coli (EPEC).   Molec. Microbiol., 48, 507-521.


Pickard, K., Dhillon, J., Mitchison, D., Butcher, P., & O'Connor, C.D. (2002).  Proteomic identification of proteins of Mycobacterium tuberculosis that are differentially expressed in the host.   Molec. & Cellular Proteomics, 1 , 658.


Skipp, P., Farooqui, M., Evans, A., & O'Connor, C.D. (2002).  Desorption/Ionisation on Silicon (DIOS): Highly reproducible, enhanced surfaces for proteomics.   Molec. Cell. Proteomics, 1, 690.


Cochrane, B. & O'Connor, C.D. (2002).  Proteomic analysis of osmotic stress responses in Salmonella.   Molec. & Cellular Proteomics, 1, 686.


O'Connor, C.D. (2002).  Centre for Proteomic Research' Resource CD – 11 Mb interactive software package.   Macromedia Flash-MX format.


Ikeda, J.S., Schmitt, C.K., Darnell, S.C., Watson, P.R., Bramley, J., Wallis, T.S., Weinstein, D.L., Metcalf, E.S., Adams, P., O'Connor , C.D. & Alison D. O'Brien (2001).  Flagellar phase variation of Salmonella enterica ser. Typhimurium contributes to virulence in the murine typhoid model but is not relevant in the calf gastroenteritis or tissue culture models.   Infect. Immun., 69, 3021-3030.


Grant, A.J., Haigh, R., Williams, P., & O'Connor, C.D. (2001).  An in vitro transposon system for highly regulated gene expression: construction of E. coli strains with arabinose-dependent growth at low temperatures.   Gene, 280, 145-151.


Owens, R.M., Grant, A., Davies, N., & O'Connor, C.D. (2001).  Co-purification of the Lac repressor with polyhistidine-tagged proteins in immobilized metal affinity chromatography.   Protein Purification and Expression, 21, 352-360.


Adams, P., Fowler, R., Kinsella, N., Howell, G., Farris, M., Coote, P., & O'Connor, C. D. (2001).  Proteomic detection of PhoPQ- and acid-mediated repression of Salmonella motility.   Proteomics, 1, 597-607.


Lissenden, S., Mohan, S., Overton, T., Regan, T., Crooke, H., Cardinale, J.A., Householder, T.C., Adams, P., O'Connor, C.D., Clark, V.L., Smith, H. & Cole, J.A. (2000).  Identification of transcription activators which regulate gonococcal adaptation from aerobic to anaerobic or oxygen-limited growth.   Molec. Microbiol., 37, 839-855.


Barker, H., Kinsella, N., Jaspe, A., Friedrich, T., & O'Connor, C.D. (2000).  Formate protects stationary phase Escherichia coli and Salmonella cells from killing by a cationic antimicrobial peptide.   Molec.Microbiol., 35, 1518-1529.


O'Connor, C.D., Adams, P., Alefounder, P., Farris, M., Kinsella, N., Li, Y., Payot, S. & Skipp, P. (2000).  The analysis of microbial proteomes: strategies and data exploitation.   Electrophoresis, 21, 1178-1186.


O'Connor, C.D., Adams, P., & Skipp, P. (1999).  New proteomic approaches for multi-analyte characterisation.   Clin. Chem. Lab. Med., 37, 81.


Pittman, J.K., Mills, R.F., O'Connor, C.D., & Williams, L.E. (1999).  Two additional type IIA Ca2+-ATPases are expressed in Arabidopsis thaliana: evidence that TypeIIA sub-groups exist.   Gene, 236, 137-147.


Adams, P., Fowler, R., Howell, G., Kinsella, N., Skipp, P., Coote, P. & O'Connor, C.D. (1999).  Defining protease specificity with proteomics: A protease with a dibasic amino acid recognition motif is regulated by a two-component signal transduction system in Salmonella.   Electrophoresis, 20, 2241-2247.


Adams, P., East, J.M., Lee, A.G., & O'Connor, C.D. (1998).  Mutational analysis of trans-membrane helices M3, M4, M5 and M7 of the fast-twitch Ca2+-ATPase.   Biochem. J., 335, 131-138.


Farris, M., Grant, A., Richardson, T.B., & O'Connor, C.D. (1998).  BipA: a tyrosine-phosphorylated GTPase that mediates interactions between enteropathogenic Escherichia coli (EPEC) and epithelial cells.   Molec. Microbiol., 28, 265-279.


Rice, J.R., Sleigh, M.A., Burkill, P.H., Tarran,, G.A., O'Connor, C.D., & Zubkov, M.V. (1997).  Flow cytometric analysis of characteristics of hybridisation of species-specific fluorescent oligonucleotide probes to rRNA of marine nanoflagellates.   Applied. Environ. Microbiol., 63, 938-944.


Amaratunga, K., Goodwin, P.M., O'Connor, C.D., & Anthony, C. (1997).  The methanol oxidation genes mxaFJGIR(S)ACKLD in Methylobacterium extorquens.   FEMS Microbiol. Lett., 146, 31-38.


Rice, J.R., O'Connor, C.D., Sleigh, M.A., Burkill, P.H., & Zubkov, M.V. (1997).  Fluorescent oligonucleotide probes that specifically bind to the rRNA of a common nanoflagellate.   Microbiology, 143, 1717-1727.


O'Connor, C.D. & Qi, S. Y. (1996).  Bacterial responses to host-defense peptides.   Trends Microbiol, 4, 128-129.


O'Connor, C.D., Farris, M., Fowler, R., & Qi, S. Y. (1996).  The proteome of Salmonella typhimurium: Current progress on its determination and some applications.   Electrophoresis, 18, 1483-1490.


Qi, S. Y., Moir, A., & O'Connor, C.D. (1996).  Proteome of Salmonella typhimurium SL1344: Identification of novel abundant cell envelope proteins and assignment to a two-dimensional reference map.   J. Bacteriol., 178, 5032-5038.


Qi, S. Y., Li, A., Szyroki, A., Giles, I.G., Moir, A., & O'Connor, C.D. (1995).  Salmonella typhimurium responses to a bactericidal protein from human neutrophils.   Molec. Microbiol., 17, 523-531.


Man, W. J., Li, Y., O'Connor, C.D., & Wilton, D.C. (1995).  The binding of propionyl-CoA and carboxymethyl-CoA to Escherichia coli citrate synthase.   Biochim. Biophys. Acta, 1250, 69-75.


Man, W., Li, Y., O'Connor, C.D., & Wilton, D.C. (1994).  The effect of replacing the conserved active site residues His-264, Asp312 and Arg-314 on the binding and catalytic properties of Escherichia coli citrate synthase.   Biochem. J., 300, 765-770.


Qi, S.Y., Li, Y., & O'Connor, C.D. (1994).  The region around residue 115 of Human Bactericidal/Permeability Increasing Protein is not involved in lipopolysaccharide binding or Bactericidal Activity. Chemical synthesis and expression of a gene coding for the active domain and chara.   Biochem. J., 298, 711-718.


O'Connor, C.D. (1993).  Curious case of the mouse that dies in the sunshine.   The Independent. 5th November 1993 (Newspaper Article on unusual effect on computer mice).


Harrison, J.L., Taylor, I.M., Platt, K., & O'Connor, C.D. (1992).  Surface exclusion specificity of the TraT lipoprotein is determined by single alterations in a five-amino-acid region of the protein.   Molec. Microbiol., 6, 2825-2832.


Al-Bar, O.A.M., O'Connor, C.D., Giles, I.G., & Akhtar, M. (1992).  D-Alanine:D-alanine ligase of Escherichia coli. Expression, purification and inhibitory studies on the cloned enzyme.   Biochem. J., 282, 747-752.


Smith, Z. & O'Connor, C.D. (1992).  The polymerase chain reaction: Development of a practical illustrating its use.   Biochem. Ed., 20, 180-182.


Man, W., Li, Y., O'Connor, C.D., & Wilton, D.C. (1991).  Conversion of citrate synthase to citryl CoA lyase as a result of mutation of the active site aspartic acid residue to glutamic acid.   Biochem. J., 280, 521-526.


Qi, S. Y., Sukupolvi, S., & O'Connor, C.D. (1991).  Outer membrane permeability of Escherichia coli K 12: isolation, cloning and mapping of extragenic suppressors of a defined antibiotic hypersensitive mutant.   Molec. Gen. Genet., 229, 421-427.


Tunwell, R., O'Connor, C.D., Mata, A.M., East, J.M., & Lee, A.G. (1991).  Mapping epitopes on the (Ca2+-Mg2+) ATPase of sarcoplasmic reticulum using fusion proteins.   Biochim. Biophys. Acta, 1073, 585-592.


Sukupolvi, S. & O'Connor, C.D. (1990).  TraT lipoprotein, a plasmid specified mediator of interactions between Gram negative bacteria and their environment.   Microbiol Rev., 54, 331-341.


Sukupolvi, S., Vuorio, R., Qi, S.Y., O'Connor, C.D., & Rhen, M. (1990).  Characterisation of the traT gene and mutants that increase outer membrane permeability from the Salmonella typhimurium virulence plasmid.   Molec. Microbiol., 4, 49 -57.


Taylor, I.M., Harrison, J.L., Timmis, K.N., & O'Connor, C.D. (1990).  The TraT lipoprotein as a vehicle for the transport of foreign antigenic determinants to the cell surface of Escherichia coli K 12: Structure function relationships in the TraT protein.   Molec. Microbiol., 4, 1259-1268.


Harrison, J.L., Taylor, I.M., & O'Connor, C.D. (1990).  Presentation of foreign antigenic determinants at the bacterial cell surface using the TraT lipoprotein.   Research in Microbiology, 141, 1009-1012.


Kaszubska, W., Aiken, C., O'Connor, C.D., & Gumport, R.I. (1989).  Purification, cloning and sequence analysis of RsrI DNA methyltransferase: Lack of homology between two enzymes, RsrI and EcoRI, that methylate the same nucleotide in identical recognition sequences.   Nucleic Acids Res, 17, 10403-10425.


Rhen, M., O'Connor, C.D., & Sukupolvi, S. (1988).  The outer membrane permeability mutation of the virulence-associated plasmid of Salmonella typhimurium is located in a traT-like gene.   FEMS Microbiol. Lett., 52, 145-154.


Sukupolvi, S., O'Connor, C.D., & Mäkelä, P.H. (1987).  The effects of traT insertion mutations on detergent sensitivity and serum resistance of Escherichia coli and Salmonella typhimurium.   FEMS Microbiol. Lett., 43, 81-87.


Sukupolvi, S. & O'Connor, C.D. (1987).  Amino acid alterations in a hydrophobic region of the TraT protein of R6-5 increase the outer membrane permeability of enteric bacteria.   Mol. Gen. Genet., 210, 178-180.


O'Connor, C.D. & Timmis, K.N. (1987).  Highly repressible expression system for cloning genes that specify potentially toxic proteins.   J. Bacteriol., 169, 4457-4462.


O'Connor, C.D., Walker, J.N.B., & Saunders, J.R. (1987).  RsrII: A restriction endonuclease with a heptanucleotide recognition site.   Meth. Enzymol., 155, 11-15.


Sukupolvi, S., O'Connor, D. C., & Edwards, M.F. (1986).  The TraT protein is able to normalise the phenotype of a plasmid-carried permeability mutation of Salmonella typhimurium.   J. Gen. Microbiol., 132, 2079-2085.


O'Connor, C.D., Metcalf, E., Wrighton, C.J., Harris, T.J.R., & Saunders, J.R. (1984).  RsrII – a novel restriction endonuclease with a heptanucleotide recognition site.   Nucleic Acids Res, 12, 6701-6708.


O'Connor, C.D. & Humphreys, G.O. (1982).  Expression of the EcoRI restriction-modification system and the construction of positive-selection cloning vectors.   Gene, 20, 219-229.


Publications 

O'Connor, C.D. & Hames, B.D.(Editors) (2007).  Proteomics – Methods Express Scion Publishing Ltd.  


O'Connor, C.D. & Smith, D.G.E (Editors) (2003).  Microbial subversion of host cells. Cambridge University Press [A].  


Publications 

O'Connor, C.D., Clarke, I.N., & Skipp, P. (2006). Quest for complete proteome coverage. In I. Humphery-Smith and M. Hecker. (Eds.), Microbial Proteomics: Functional Biology of Whole Organisms (pp. 27-38). Wiley, New York. 


Skipp, P., Farooqui, M., Pickard, K., Li, Y., Evans, A.G.R., & O'Connor, C.D., (2004). Expanding the information window to increase proteomic sensitivity and selectivity. In J.J. Valdes and J.W. Sekowski. (Eds.), Proceedings of NATO Advanced workshop on Proteomics and Toxicogenomics (pp. 33-42). IOS Press, Amsterdam, The Netherlands. 


Pickard, K. & O'Connor, C.D. (2002). Protein chips and microarrays. Microarrays and Microplates: Applications in Biomedical Sciences (pp. 61-88). Bios publishing: S. Ye and I.M.N. Day. 


O'Connor, C.D., Farris, M., Hunt, L.G., & Wright, J.N. (1998). The Proteome Approach in Methods in Microbiology. In P. Williams, G. Salmond and J. Ketley (Eds.), . Academic Press. 


Research Grants 

Research

2013: O'Connor, D. C. >RMB 60,000,000 of grants previously as principal applicant or co-principal applicant.