Tatsuhiko Kadowaki


Qualifications

Ph.D.   Case Western Reserve University,  1994

M.S.   Nagoya University,  Japan,  Agriculture,  1988

B.A.   Yamaguchi University,  Japan,  Agriculture,  1986


Experience

Graduate Studies Officer

Associate Professor, Department of Biological Sciences, XJTLU (September, 2011 - Present), Suzhou, China-PRC.

Associate Professor, Graduate School of Bioagricultural Sciences, Nagoya University (April, 1999 - August, 2011), Nagoya, Japan.

Postdoctoral fellow, Department of Physiology, University of California San Francisco School of Medicine (January, 1999 - March, 1999), San Francisco, United States of America.

JSPS research fellow, Department of Developmental Biology, HHMI, Stanford University School of Medicine (January, 1998 - December, 1998), Stanford, United States of America.

JSPS research fellow, BioScience Center, Nagoya University (April, 1996 - December, 1997), Nagoya, Japan.

JSPS research fellow, Department of Genetics, HHMI, Harvard Medical School (January, 1996 - March, 1996), Massachusetts, United States of America.

Postdoctoral fellow, Department of Genetics, HHMI, Harvard Medical School (April, 1994 - December, 1995), Massachusetts, United States of America.

Postdoctoral fellow, Institute of Pathology, Case Western Reserve University School of Medicine (January, 1988 - March, 1994), Cleveland, United States of America.



Professional Service Activities 

Board Member: PRJ Editorial Review Board

2013:  Applied Ecology and Environmental Sciences (International).

2011:  Frontiers in Evolutionary and Population Genetics (International).  2011-present: Associate Editor


Board of Directors: Substantial Involvement

2004:  JAACT (Japan Association of Animal Cell Technology) (International).  Apr. 2004-Mar. 2008


Reviewer - Article / Manuscript

2006:  Several Journals (International).  Zoological Science;
Applied Entomology and Zoology;
Insect Molecular Biology;
European Journal of Neuroscience;
Naturwissenschaften;
FEBS Letters;
Molecular Biology and Evolution;
Journal of Neuroscience;
Journal of Virological Methods;
African Journal of Biotechnology;
PLoS ONE;
Virus Research;
Insects;
Viruses.
Insect Biochemistry and Molecular Biology
Journal of Invertebrate Pathology
Parasitology
Frontiers in Physiology


Reviewer - Grant Proposal Related to Expertise

2014:  German-Israel Foundation for Scientific Research and Development (International).

2011:  Postdoctoral Research Fellowship and International Cooperative Research Grant applications (JSPS) (National).


Invited Lecture

2012:  Okazaki Institute for Integrative Bioscience, Japan (International).  Invitation to speak: Evolution and Ecophysiology of insect thermosensitive TRP channels", Summer School 2012 "Thermal Biology: from plants to humans

2011:  School of Life Sciences, Xiamen University, PRC (Local).  Invitation to speak: Evolution and Ecophysiology of insect TRP channels

2009:  International Symposium 2009 for Health care, Woosuk University, Korea (International).  Invitation to speak: Honey bee Genome, Sensory system, and Disease


Professional Service Activities 

Board Member: PRJ Editorial Review Board

2013:  Applied Ecology and Environmental Sciences (International).

2011:  Frontiers in Evolutionary and Population Genetics (International).  2011-present: Associate Editor


Board of Directors: Substantial Involvement

2004:  JAACT (Japan Association of Animal Cell Technology) (International).  Apr. 2004-Mar. 2008


Reviewer - Article / Manuscript

2006:  Several Journals (International).  Zoological Science;
Applied Entomology and Zoology;
Insect Molecular Biology;
European Journal of Neuroscience;
Naturwissenschaften;
FEBS Letters;
Molecular Biology and Evolution;
Journal of Neuroscience;
Journal of Virological Methods;
African Journal of Biotechnology;
PLoS ONE;
Virus Research;
Insects;
Viruses.
Insect Biochemistry and Molecular Biology
Journal of Invertebrate Pathology
Parasitology
Frontiers in Physiology

Reviewer - Grant Proposal Related to Expertise

2014:  German-Israel Foundation for Scientific Research and Development (International).

2011:  Postdoctoral Research Fellowship and International Cooperative Research Grant applications (JSPS) (National).


Invited Lecture

2012:  Okazaki Institute for Integrative Bioscience, Japan (International).  Invitation to speak: Evolution and Ecophysiology of insect thermosensitive TRP channels", Summer School 2012 "Thermal Biology: from plants to humans

2011:  School of Life Sciences, Xiamen University, PRC (Local).  Invitation to speak: Evolution and Ecophysiology of insect TRP channels

2009:  International Symposium 2009 for Health care, Woosuk University, Korea (International).  Invitation to speak: Honey bee Genome, Sensory system, and Disease


Professional Memberships 

Molecular Biology Society of Japan, 1999-present


Honors and Awards 

2011:  SIP (Suzhou Industrial Park) Jinji Lake Double-Hundred Talents Program 2011, Suzhou Industrial Park.

1996:  Japan Society for the Promotion of Science Postdoctoral Research Fellowship, Japan Society.  1996-1998.

1986:  Suntory Scholarship for Graduate Students, Unknown.  1986-1988.


Research Interests 

Research Interests

1. Biological basis of honey bee decline
Large-scale losses of European honey bee colonies have been recently reported in several developed countries. These extensive colony losses are not unusual, and have occurred repeatedly at many locations in a long history of apiculture. Nevertheless, honey bee pollination provides a critical ecosystem function that is also necessary for production of a variety of agricultural crops at present. Thus, prevention of honey bee losses is a central issue in the current apiculture. We study the roles of host-pathogen interactions for honey bee diseases and the genomic characterization of parasitic mites of honey bee.

2. Adaptation of sensory systems toward novel environments and its implications in speciation
The idea that speciation has been driven by the novel phenotypes gained through adaptation to local environments is the backbone of Darwin's evolutionary theory. We study how the functions of proteins involved in thermal sensation including Transient Receptor Potential channels have been modified through thermal adaptation, and whether these events have contributed to the speciation of Arthropod species. It will be possible to propose a new hypothesis about the mechanisms of adaptation of sensory systems to local environments as well as their roles for speciation.


Publications 

Peng, G., Shi, X., & Kadowaki, T. (2015).  Evolution of TRP channels inferred by their classification in diverse animal species.   Molecular Phylogenetics and Evolution, 84, 145-157.


Kadowaki, T. (2015).  Evolutionary dynamics of metazoan TRP channels.   Pflügers Arch, 467, 2043–2053.


Sadd, B. M. (2015).  The genomes of two key bumble bee species with primitive eusocial organization.   Genome Biol, 16, 76.


Ravoet, J. (2015).  Differential diagnosis of the honey bee trypanosomatids Crithidia mellificae and Lotmaria passim.   J. Invertebr. Pathol, 130, 21-27.


Peng, G., Kashio, M., Morimoto, T., Li, T., & Zhu, J. (2015).  Plant-derived tick repellents activate the honey bee ectoparasitic mite TRPA1.   Cell Reports, 12, 190-202.


Yang, B., Peng, G., Li, T., & Kadowaki, T. (2013).  Molecular and phylogenetic characterization of honey bee viruses, Nosema microsporidia, protozoan parasites, and parasitic mites in China.   Ecol. Evol (3), 298-311.


Morimoto, T., Kojima, Y., Yoshiyama, M., Kimura, K., Yang, B., Peng G. Kadowaki T. (2013).  Molecular detection of protozoan parasites infecting Apis mellifera colonies in Japan.   Environ. Microbiol. Rep (3), 74-77.


Morimoto, T., Kojima, Y., Yoshiyama, M., Kimura, K., Yang, B., Kadowaki T. (2012).  Molecular identification of Chronic bee paralysis virus infection in Apis mellifera colonies in Japan.   Viruses (4), 1093-1103.


Kojima, Y., Toki, T., Morimoto, T., Yoshiyama, M., Kimura, K., Kadowaki T (2011).  Infestation of Japanese native honey bees by tracheal mite and virus from non-native European honey bees in Japan.   Microbial Ecol, 62, 895-906.


Kojima, Y., Yoshiyama, M., Kimura, K., & Kadowaki, T. (2011).  PCR-based detection of a tracheal mite of the honey bee Acarapis woodi.   J. Invertebr. Pathol, 108, 135-137.


Hakuno, F., Yamauchi, Y., Kaneko, G., Kaneko, G., Yoneyama, Y., Nakae J, Chida K, Kadowaki T, Yamanouchi K, Nishihara M, and Takahashi S-I. (2011).  Constitutive expression of insulin receptor substrate (IRS)-1 inhibits myogenic differentiation through nuclei exclusion of Foxo1 in L6 myoblasts.   PLoS ONE (6), e25655.


Morimoto, T., Kojima, Y., Toki, T., Komeda, Y., Yoshiyama, M., Kimura K, Nirasawa K, and Kadowaki T (2011).  The habitat disruption induces immune-suppression and oxidative stress in honey bees.   Ecol. Evol (1), 201-217.


Kohno, K., Sokabe, T., Tominaga, M., & Kadowaki, T. (2010).  Honey bee thermal/chemical sensor, AmHsTRPA, reveals neofunctionalization and loss of Transient Receptor Potential channel genes.   J. Neurosci, 30, 12219-12229.


The Nasonia Genome Working Group, T. (2010).  Functional and evolutionary insights from the genomes of three parasitoid Nasonia species.   Science (327), 343-348.


Matsuura, H., Sokabe, T., Kohno, K., Tominaga, M., & Kadowaki, T. (2009).  Evolutionary conservation and changes in insect TRP channels.   BMC Evol. Biol (9), 228.


Higuchi, N., Kohno, K., & Kadowaki, T. (2009).  Specific retention of the protostome-specific PsGEF may parallel with the evolution of mushroom bodies in insect and lophotrochozoan brains.   BMC Biol. (7), 21.


Matsui, T., Yamamoto, T., Wyder, S., Zdobnov, E., & Kadowaki, T. (2009).  Expression profiles of Urbilaterian genes uniquely shared between honey bee and vertebrates.   BMC Genomics (10), 17.


Phan, H., Ezure, T., Ito, M., Kadowaki, T., Kitagawa, Y., Niimi T (2008).  Expression and chain assembly of human laminin-332 in an insect cell-free translation system.   Biosci. Biotechnol. Biochem (72), 1847-1852.


Tribolium Genome Sequencing Consortium, T. (2008).  The genome of the model beetle and pest Tribolium castaneum.   Nature (452), 949-955.


Sokabe, T., Tsujiuchi, S., Kadowaki, T., & Tominaga, M. (2008).  Drosophila Painless is a Ca2+-requiring channel activated by noxious heat.   J. Neurosci (28), 9929-9938.


Wyder, S., Kriventseva, E., Schröder, R., Kadowaki, T., & Zdobnov, E. (2007).  Quantification of ortholog losses in insects and vertebrates.   Genome Biol (8), R242.


Funada, M., Hara, H., Sasagawa, H., Kitagawa, Y., & Kadowaki, T. (2007).  A honey bee Dscam family member, AbsCAM, is a brain-specific cell adhesion molecule with the neurite outgrowth activity which influences neuronal wiring during development.   Eur. J. Neurosci (25), 168-180.


Tsujiuchi, S., Sivan-Loukianova, E., Eberl, D., Kitagawa, Y., & Kadowaki, T. (2007).  Dynamic range compression in the honey bee auditory system toward waggle dance sounds.   PLoS ONE (2), e234.


Galli, L., Barnes, T., Secrest, S., Kadowaki, T., & Burrus, L. (2007).  Porcupine-mediated lipid-modification regulates the activity and distribution of Wnt proteins in the chick neural tube.   Development (134), 3339-3348.


The honeybee genome sequencing consortium, T. (2006).  Insights into social insects from the genome of the honey bee Apis mellifera.   Nature (443), 931-949.


Dearden, P., Wilson, M., Sablan, L., Osborne, P., Havler, M., McNaughton E, Kimura K, Milshina NV, Hasselmann M, Gempe T, Schioett M, Brown SJ, Elsik CG, Holland PWH, Kadowaki T, and Beye M (2006).  Patterns of conservation and change in honey bee developmental genes.   Genome Res (16), 1376-1384.


Tsuchimoto, M., Yasuo, S., Funada, M., Aoki, M., Sasagawa, H., Yoshimura T, Tadauchi O, Cameron SA, Kitagawa Y, and Kadowaki T (2005).  Conservation of novel Mahya genes shows the existence of neural functions common between Hymenoptera and Deuterostome.   Dev. Genes Evol (215), 564-574.


Yamashita, H., Goto, A., Kadowaki, T., & Kitagawa, Y. (2004).  Mammalian and Drosophila cells adhere to the laminin alpha4 LG4 domain through syndecans but not glypicans.   Biochem. J (382), 933-943.


Funada, M., Yasuo, S., Yoshimura, T., Ebihara, S., Sasagawa, H., Kitagawa Y, and Kadowaki T (2004).  Characterization of the two distinct subtypes of metabotropic glutamate receptors from honeybee, Apis mellifera.   Neurosci. Lett (359), 190-194.


Tanaka, K., Kitagawa, Y., & Kadowaki, T. (2003).  Misexpression of mouse porcupine isoforms modulates the differentiation of P19 embryonal carcinoma cells.   Cell Biol. Int (27), 549-557.


Goto, A., Kadowaki, T., & Kitagawa, Y. (2003).  Drosophila hemolectin gene is expressed in embryonic and larval hemocytes and its knock down causes bleeding defects.   Dev. Biol (264), 582-591.


Tsuchimoto, M., Aoki, M., Takada, M., Kanou, Y., Sasagawa, H., Kitagawa Y, and Kadowaki T (2003).  The changes of gene expression in honeybee (Apis mellifera) brains associated with ages.   Zoolog. Sci (21), 23-28.


Sasagawa, H., Narita, R., Kitagawa, Y., & Kadowaki, T. (2003).  The expression of genes encoding visual components is regulated by a circadian clock, light environment and age in the honeybee (Apis mellifera).   Eur. J. Neurosci (17), 963-970.


Tanaka, K., Kitagawa, Y., & Kadowaki, T. (2002).  Drosophila segment polarity gene product Porcupine stimulates the posttranslation N-glycosylation of Wingless in the Endoplasmic reticulum.   J. Biol. Chem (227), 12816-12823.


Yanagawa, S., Matsuda, Y., Lee, J., Matsubayashi, H., Sese, S., Kadowaki T, and Ishimoto A (2002).  Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila.   EMBO J (21), 1733-1742.


Goto, A., Kumagai, T., Kumagai, C., Hirose, J., Narita, H., Mori H, Kadowaki T, Beck K, and Kitagawa Y. A (2001).  Drosophila haemocyte-specific protein, hemolectin, similar to human von Willebrand factor.   Biochem. J. (359), 99-108.


Goto, A., Matsushima, Y., Kadowaki, T., & Kitagawa, Y. (2001).  Drosophila mitochondrial transcription factor A (d-TFAM) is dispensable for the transcription of mitochondrial DNA in Kc167 cells.   Biochem. J (354), 243-248.


Thumm, M. & Kadowaki, T. (2001).  The loss of Drosophila APG4/AUT2 function modifies the phenotypes of cut and Notch signaling pathway mutants.   Mol. Genet. Genomics (266), 657-663.


Kumagai, T., Yokoyama, H., Goto, A., Hirose, J., & Kadowaki, T. (2000).  Narita H, and Kitagawa Y. Screening for Drosophila proteins with distinct expression patterns during development by use of monoclonal antibodies.   Biosci. Biotechnol. Biochem (64), 24-28.


Tanaka, K., Okabayashi, K., Asashima, M., & Perrimon, N. (2000).  The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.   Eur. J. Biochem (267), 4300-4311.


Kumagai, C., Kadowaki, T., & Kitagawa, Y. (1997).  Disulfide-bonding between Drosophila laminin beta and gamma chains is essential for alpha chain to form alpha beta gamma trimer.   FEBS Lett (412), 211-216.


Inagaki, H., Matsushima, Y., Nakamura, K., Ohshima, M., Kadowaki, T., Kitagawa Y (1996).  A large DNA-binding nuclear protein with RNA recognition motif and serine/argine-rich domain.   J. Biol. Chem (271), 12525-12531.


Kadowaki, T., Wilder, E., Klingensmith, J., Zachary, K., & Perrimon, N. (1996).  The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing.   Genes & Dev (10), 3116-3128.


Kadowaki, T., Schneiter, R., Hitomi, M., & Tartakoff, A. (1995).  Mutations in nucleolar proteins lead to nucleolar accumulation of polyA+ RNA in Saccharomyces cerevisiae.   Mol. Biol. Cell (6), 1103-1110.


Schneiter, R., Kadowaki, T., & Tartakoff, A. (1995).  mRNA transport in yeast: time to reinvestigate the functions of the nucleolus.   Mol. Biol. Cell (6), 357-370.


Kadowaki, T., Hitomi, M., Chen, S., & Tartakoff, A. (1994).  Nuclear mRNA accumulation causes nucleolar fragmentation in yeast mtr2 mutant.   Mol. Biol. Cell (5), 1253-1263.


Kadowaki, T., Chen, S., Hitomi, M., Jacobs, E., Kumagai, C., Liang S, Schneiter R, Singleton D, Wisniewska J, and Tartakoff AM (1994).  Isolation and characterization of Saccharomyces cerevisiae mRNA transport-defective (mtr) mutants.   J. Cell. Biol (126), 649-659.


Kadowaki, T., Goldfarb, D., Spitz, L., Tartakoff, A., & Ohno, M. (1993).  Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily.   EMBO J (12), 2929-2937.


Kadowaki, T., Zhao, Y., & Tartakoff, A. (1992).  A conditional yeast mutant deficient in mRNA transport from nucleus to cytoplasm.   Proc. Natl. Acad. Sci. USA (89), 2312-2316.


Kadowaki, T. & Kitagawa, Y. (1991).  Hypoxic depression of mitochondrial mRNA levels in HeLa cells.   Exp. Cell Res (192), 243-247.


Kadowaki, T. & Kitagawa, Y. (1988).  Enhanced transcription of mitochondrial genes after growth stimulation and glucocorticoid treatment of Reuber hepatoma H-35.   FEBS Lett (233), 51-56.


Research Grants 

Research

2012 [Year 2 of 3]: Kadowaki, T. Development of novel technology to control a major pest of apiculture industry, Principal Investigator, Suzhou Science and Technology Development Planning Programme.


Tatsuhiko Kadowaki (PI). Two students and one research assistant. 2012-2016, 45,000 RMB, Project values (20%),


2011: Kadowaki, T. identification of major pathogens and parasites causing honey bee diseases and development of their control methods, Principal Investigator, Yamada Research Grant - from Nagoya University.


2010: Kadowaki, T. Infrastructure development for sustainable apiculture, horticulture, and ecosystem by conservation of honey bees, Mitsui & Co., Ltd. Environment Fund. Tatsuhiko Kadowaki (PI). 2010-2011, 10 million JPY.


2010: Kadowaki, T. Advancement of apiculture technology and honey bee usage for crop pollination, Ministry of Agriculture, Forestry and Fisheries (MAFF). Keijiro Nirasawa (PI), and five other researchers. 2010-2012, 26.8 million JPY
Grant-in-Aid for Scientific Research on Priority Areas from MAFF.


2010: Kadowaki, T. Basic research on honey bee conservation to support sustainable apiculture, horticulture, and ecosystem, Japan Society for the Promotion of Science (JSPS). Tatsuhiko Kadowaki (PI). 2010-2011, 16.8 million JPY
Grant-in-Aid for Scientific Research (B) from JSPS.


2009: Kadowaki, T. Epidemiological investigation of honey bees in Japan and characterization of novel honey bee pathogens, The Sumitomo Foundation. Tatsuhiko Kadowaki (PI). 2009-2010, 2.1 million JPY.


2009: Kadowaki, T. Development of prevention against major pathogens causing honey bee diseases in Japan, Yamada Bee Farm Grant for Honey bee Research. Tatsuhiko Kadowaki (PI). 2009-2011, 3 million JPY.


2009: Kadowaki, T. Nationwide survey of honey bee pathogens and identification of major factors influencing honey bee health conditions in Japan, Ministry of Agriculture, Forestry and Fisheries (MAFF). Kiyoshi Kimura (PI) and Tatsuhiko Kadowaki. 2009-2010, 2 million JPY.
Grant-in-Aid for Scientific Research on Priority Areas from MAFF.


2009: Kadowaki, T. Roles of Drosophila thermo-sensitive TRP channels on adaptation to environments as well as speciation, Ministry of Education, Culture, Sports, Science & Technology (MEXT). Tatsuhiko Kadowaki (PI).2009-2011, 6 million JPY Grant-in-Aid for Scientific Research on Priority Areas from MEXT.


2008: Kadowaki, T. Research on the prevention and causes of honey bee CCD, Japan Society for the Promotion of Science (JSPS). Tatsuhiko Kadowaki (PI). 2008-2010, 3.5 million JPY
Grant-in-Aid for Challenging Exploratory Research from JSPS.


2008: Kadowaki, T. Identification of the causes of honey bee CCD by field survey, Yamada Bee Farm Grant for Honey bee Research. Tatsuhiko Kadowaki (PI). 2008-2009, 1.7 million JPY.


2007: Kadowaki, T. Application of insect auditory system to develop supersensitive sound and vibration sensors, Nagoya University Akasaki Research Grant. Tatsuhiko Kadowaki (PI). 2007-2008, 1.8 million JPY.


2007: Kadowaki, T. Application of insect auditory system to develop supersensitive sound and vibration sensors, Mitutoyo Association for Science and Technology Research Grant. Tatsuhiko Kadowaki (PI). 2007-2008, 2 million JPY.


2005: Kadowaki, T. Basic research on honey bee auditory system to develop microsensors, Japan Society for the Promotion of Science (JSPS). Tatsuhiko Kadowaki (PI). 2005-2007, 2.7 million JPY
Grant-in-Aid for Challenging Exploratory Research from JSPS.


2004: Kadowaki, T. Development of insect sensory and motion system based robots and microsensors, Joint Research Grant of Nagoya University-Mitsubishi Heavy Industries, LTD. Tatsuhiko Kadowaki (PI). 2004-2005, 0.5 million JPY
.


2003: Kadowaki, T. Basic research on the development of regenerative medicine with mesenchymal stem cells, Japan Society for the Promotion of Science (JSPS). Tatsuhiko Kadowaki (PI). 2003-2005, 3.6 million JPY
Grant-in-Aid for Scientific Research (C) from JSPS.


2002: Kadowaki, T. Functional characterization of the acylation of Wnt family proteins, Ministry of Education, Culture, Sports, Science & Technology (MEXT). Tatsuhiko Kadowaki (PI). 2002-2004, 6.8 million JPYGrant-in-Aid for Scientific Research on Priority Areas (A) from MEXT.


2000: Kadowaki, T. Mechanisms of the biosynthesis of Wnt family proteins in endoplasmic reticulum, Japan Society for the Promotion of Science (JSPS). Tatsuhiko Kadowaki (PI). 2000-2002, 3.4 million JPY
Grant-in-Aid for Scientific Research (C) from JSPS.